After the last two years of pandemic, economic collapse, and the she-cession, it’s time to return to a topic near and dear to this columns’ heart: entrepreneurship. There is nothing that warms said heart quite as much as the idea of a bunch of ambitious young women out there forging their own paths and transforming the world. There’s excitement, heightened by the sense—even back in the 1990s, when I founded my company—of helping to break new ground. And in the decades since, it’s been a distinct pleasure to watch women like Marissa Mayer, Sheryl Sandberg, Jane Fraser, and Safra Catz rise up alongside a whole generation of female business leaders. But unfortunately, there’s no way to talk about the entrepreneurial spirit in 2022 without also talking about the pandemic and its consequences.