Chawla flew on two Space Shuttle missions as a mission specialist. On November 19, 1997, she launched on board Space Shuttle Columbia as part of STS-87. Chawla specialized in operating the robotic arm, which she used to deploy the Spartan Satellite. During the 16-day mission, the crew conducted numerous experiments, with a focus on materials science. Chawla made history as the first Indian woman, and the first South Asian American woman, to fly in space. Indian Prime Minister Inder Kumal Gujral called Chawla in space to congratulate her on her journey and express pride in her representing India in space.
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